Peptide compound research profiles
Mechanism, published studies, safety signals, and regulatory status for the most-researched peptides. Every profile is source-cited and labeled by evidence strength, from in-vitro through FDA-approved.
Start with: Are peptides safe?
BPC-157
A 15-amino-acid peptide derived from a gastric protein, studied preclinically for tendon, gut, and vascular repair.
TB-500
Synthetic actin-binding fragment of Thymosin beta-4 studied preclinically for cell migration, angiogenesis, and wound repair.
GHK-Cu
Copper-binding tripeptide with human topical evidence for skin remodeling and collagen synthesis; injectable use largely unstudied.
Semaglutide
FDA-approved GLP-1 receptor agonist; the most extensively studied metabolic peptide, with landmark diabetes, obesity, and cardiovascular trials.
Tirzepatide
FDA-approved dual GIP/GLP-1 receptor agonist studied for glycemic control, obesity, and obstructive sleep apnea.
CJC-1295
A long-acting synthetic GHRH analog studied for sustained growth hormone and IGF-1 elevation; not FDA approved and not on the July 2026 PCAC docket.
Ipamorelin
Selective pentapeptide ghrelin-receptor agonist studied for pulsatile GH release without significant ACTH, cortisol, or prolactin rise.
MK-677
An oral non-peptide ghrelin-receptor agonist studied as a growth-hormone secretagogue; raised IGF-1 in trials but showed metabolic drawbacks and no demonstrated functional benefit.
PT-141
FDA-approved melanocortin-receptor agonist (Vyleesi) studied for hypoactive sexual desire disorder via central MC4R pathways.
Semax
Russian-developed ACTH(4-7)PGP heptapeptide studied for neuroprotection and cognition; modulates BDNF/NGF signaling. On the FDA PCAC July 2026 docket.
Selank
Synthetic tuftsin-analog heptapeptide studied in Russia as an anxiolytic and nootropic, with reported effects on GABA, serotonin, and BDNF.
MOTS-c
A 16-amino-acid mitochondrial-derived peptide studied in preclinical models for AMPK activation, insulin sensitivity, and exercise-mimetic metabolic effects.
Epitalon
Synthetic pineal-derived tetrapeptide studied for telomerase activation, melatonin/circadian regulation, and geroprotective effects — predominantly preclinical.
KPV
The C-terminal tripeptide of α-MSH studied as a receptor-independent anti-inflammatory in preclinical colitis and IBD models.
Thymosin Alpha-1
28-amino-acid thymic immunomodulator marketed abroad as Zadaxin for hepatitis B; researched in sepsis and COVID-19.
AOD-9604
Growth-hormone C-terminal fragment analog studied for fat metabolism; its largest obesity trial failed to beat placebo.